Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis

Background: It is well documented that menopause linked to an increased risk of cardiovascular (CV) events; however, the results studies focusing on association between premature ovarian insufficiency (POI) and CV events are controversial. The aim this systematic review meta-analysis was assess among women with POI compared menopausal aged 50–54 years. Methods: A literature search PubMed (including Medline), Scopus, Web Science conducted from 1990 2022 retrieve observational published in English-language. studies’ quality assessed using structured standard tools. Primary-outcome pooled composite outcome events. Results: We included 16 involving 40,549 who suffered 1,016,633 as controls. After adjustment for hormone therapy, coronary heart disease, significantly 1.3 (Pooled-adjusted hazard ratio (HR) = 1.35, 95% CI: 1.06–1.63, I2: 0%) 1.4 (Pooled adjusted HR 1.42, 1.17–1.66, fold higher than age There no difference groups regarding stroke death due two groups. not sufficient data analysis other specific Conclusions: In conclusion, associated events, particularly disease. Our findings extend prior work supporting a risk-enhancing factor However, more needed confirmed these findings.